Previous IVF Failure/Miscarriage Investigations
PREVIOUS IVF FAILURE / MISCARRIAGE INVESTIGATIONS
Reproductive Immunology
This investigation involves a blood test to ascertain whether there are any particular cells (Natural Killer cells) within the immune system which may lead to rejection of a pregnancy.
Pre Implantation Genetic Screening (PGS)
Pre-Implantaton Genetic Screening is an early method of analyzing the chromosomal make-up of embryos in order to assess the likelihood of any problems and reduce the risk of miscarriage. It is well known that over 50% of the embryos created in the laboratory will be genetically incapable of leading to a pregnancy or a healthy live birth. In order for us to conduct PGS investigations, you will be required to go through an IVF procedure to stimulate the production of embryos for screening. Following the creation of embryos a biopsy is taken of the embryos at the blastocyst stage. The embryos will have to be frozen post biopsy.
Screening includes a full Chromosome Analysis of all 24 pairs of chromosomes
TSH
The TSH (thyroid stimulating hormone) test is often the first test for evaluating thyroid function and/or symptoms of hyper- or hypothyroidism and involves a blood test. Hyper- or hypothyroidism can cause an increased risk for miscarriage.
ANA
The ANA (anti-nuclear antibodies) blood test is used to detect autoimmune disorders.
Chromosome analysis
This involves blood tests to check for chromosomal abnormalities (known as karyotyping). If the tests highlight a problem, you may be referred to our clinical geneticist for further testing.
Uterine
3DSIS
A 3D SIS (saline infusion sonography) is an ultrasound procedure performed to assess the the uterine cavity is normal. It involves passing a catheter through the neck of the womb followed by filling the womb with sterile water 3-dimensional images of the uterine cavity are then taken and assessed. This investigation is usually carried out after menstruation has ended but before ovulation between days 7-12 of the menstrual cycle.
Hysteroscopy
This investigation involves placing a narrow telescope with a camera into the womb and is used to examine the lining of the womb and the opening of the fallopian tubes, to determine whether there are any polyps, fibroids or adhesions present.
Clotting Factors
This investigation involves a blood test enabling us to assess your Thrombotic risk profile.
The test includes:
- FBC
- Coagulation profile
- Antithrombin III
- Factor V Leiden gene
- Factor II Prothrombin gene
- MTHFR gene
- Fibrinogen
- Activated Protein C Resistance
- Protein C
- Protein S
- Lupus Anticoagulant
- Anticardiolipin Ab
